Histologic and Micro-CT Findings by the Impact of Vitamin D on Osseointegration in the Ovariectomized Rat Maxilla: A Preliminary Study
박수현, 허현아, 윤현중, 표성운,
소속 상세정보
박수현 ( Park Su-Hyun ) - Catholic University College of Medicine Department of Dentistry Division of Advanced General Dentistry
허현아 ( Heo Hyun-A ) - Catholic University College of Medicine Department of Dentistry Division of Advanced General Dentistry
윤현중 ( Yoon Hyun-Joong ) - Catholic University College of Medicine Department of Dentistry Division Oral and Maxillofacial Surgery
표성운 ( Pyo Sung-Woon ) - Catholic University College of Medicine Department of Dentistry Division Oral and Maxillofacial Surgery
KMID : 1146620210100010009
Abstract
This study was aimed to determine the effect of vitamin D on bone formation around implant in the maxilla of osteoporotic rats. Fifteen female rats at 8 weeks-old were divided into three groups: 1) control group, sham-operated rats, 2) ovariectomized only group (OVX) and 3) ovariectomized and vitamin D-administered group (VitD). Eight weeks after the ovariectomy or sham operation, upper right molar was extracted, and an implant was placed at 4 weeks post-extraction. The vitamin D-administered experimental groups were given with 0.1 μg/kg/day via gavage while the OVX group and the control group received vehicle only. All rats in each group were sacrificed at 8 weeks and histologic and micro-computed tomographic (CT) evaluation were performed. According to the histologic observation, newly formed bone close to implant threads was mature with considerable quantity of bone marrow in the VitD group than the OVX group. In micro-CT findings, the VitD groups showed greater radiologic density of peri-implant bone close to implant threads than the OVX group. The results proposed that vitamin D could increase bone formation around implant. This might have clinical implications in dental implant treatment for patients with reduced bone formation capacity.
키워드
Bone formation; Dental implant; Osteoporosis; Ovariectomy; Vitamin D
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